线粒体靶向纳米颗粒PSiNPs-Rho110的制备及表征
文献综述
摘要
多孔硅是一种具有纳米结构的材料。可以通过晶体硅或非晶硅在氢氟酸中进行阳极氧化来获得。多孔硅作为一种生物相容性物质，在生物医学方面的应用也极为广泛。人们对硅半导体技术的应用逐渐受到重视,世界范围内掀起了研究多孔硅的热潮。本文通过罗丹明110介绍线粒体靶向作用。此外，已知许多抗癌药物可在线粒体被激活。因此，增强抗癌药物在线粒体的靶向积累将有助于提高治疗效果，并有可能克服耐药性问题，将抗癌药物的线粒体靶向递送策略具有较高的研究价。值通过对制备出的线粒体靶向纳米颗粒PSiNPs-Rho110及其相关性质进行表征，可以筛选出具有合适粒径和功能的纳米颗粒，对其生物学应用具有重要意义。
关键词:线粒体、多孔硅、表面改性、罗丹明
Preparation and Characterization of Mitochondrial Targeting Nanoparticles PSiNPs-Rho110
ABSTRACT
Porous silicon is a material with a nanostructure. It can be obtained by anodizing crystalline or amorphous silicon in hydrofluoric acid. Porous silicon, as a biocompatible substance, is also widely used in biomedicine. People pay more and more attention to the application of silicon semiconductor technology, and it has set off a wave of research on porous silicon worldwide. This article introduces mitochondrial targeting via rhodamine 110. In addition, many anticancer drugs are known to be activated by mitochondria. Therefore, enhancing the targeted accumulation of anticancer drugs in mitochondria will help to improve the treatment effect and possibly overcome the problem of drug resistance. Targeting the delivery of anticancer drugs to mitochondria has a high research price. By characterizing the prepared mitochondrial targeting nanoparticles PSiNPs-Rho110 and its related properties, it is possible to screen out nanoparticles with appropriate size and function, which is of great significance for their biological applications.
Key words: Mitochondria, porous silicon, surface modification, rhodamine
以上是毕业论文文献综述，课题毕业论文、任务书、外文翻译、程序设计、图纸设计等资料可联系客服协助查找。
