罗丹明靶向及CuS光热治疗
摘 要
近年来提出的近红外光介导的光热治疗，能够对肿瘤组织进行定点清除并且对正常组织具有较低的毒副作用，为肿瘤的治疗提供了新的方法。为了降低光热治疗的毒副作用并且提高光热杀伤效率，需要在治疗前确认肿瘤在体内的大小和位置，并且对光热治疗的过程进行实时的监测。核磁共振成像是一种比较理想的能够为光热治疗提供诊断辅助和实时监测的成像模式。目前，一些同时具有光热治疗效果和核磁成像功能的多功能复合纳米粒子被设计和开发出来，应用于肿瘤的诊断和治疗。然而，成本高昂、制备过程繁琐以及光热稳定性较差等不足，限制了这些纳米材料的进一步应用。最新报道的半导体硫化铜纳米粒子，制备工艺简单、成本低廉、并且具有突出的光热稳定性和良好的生物相容性，成为了当今纳米医学领域研究的热点。
关键词：光热治疗；核磁成像；CuS
Rhodamine targeting and CuS photothermal therapy
ABSTRACT
In recent years, the photothermal therapy mediated by near-infrared light has been proposed, which can perform targeted clearance of tumor tissues and has low toxic and side effects on normal tissues, providing a new method for the treatment of tumor. In order to reduce the toxic side effects of photothermal therapy and improve the photothermal killing efficiency, the size and location of the tumor in the body should be confirmed before treatment, and the process of photothermal therapy should be monitored in real time. Magnetic resonance imaging (mri) is an ideal imaging mode that can provide diagnostic assistance and real-time monitoring for photothermal therapy. At present, a number of multifunctional composite nanoparticles with both photothermal therapy and nuclear imaging have been designed and developed for the diagnosis and treatment of tumors. However, the high cost, complicated preparation process and poor photothermal stability limit the further application of these nanomaterials. Recently reported semiconductor copper sulfide nanoparticles, with simple preparation process, low cost, outstanding photothermal stability and good biocompatibility, have become a research hotspot in the field of nanomedical medicine.
Key words：photothermal therapy；MRI；CuS
目 录
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