兽疫链球菌发酵中期原位诱导纳米纤维素凝胶化文献综述

 2022-03-16 22:58:18

兽疫链球菌发酵中期原位诱导纳米纤维素凝胶化

摘 要

纳米纤维素作为一种新型的生物质纳米材料，已被证明为前景广阔的自组装水凝胶或生物基纳米填料。透明质酸因为其极强的保水能力广泛应用于医药、化妆品行业。水凝胶是一类由合成高分子和天然高分子制成的具有三维网络结构的聚合物材料，由于其高含水量和高弹性行为，水凝胶被广泛应用于组织填充材料、药物载体、软骨再生、伤口敷料和环境吸附剂等。透明质酸和纳米纤维素可结合制造出绿色安全、健康无毒的新型水凝胶复合材料。以兽疫链球菌为诱导物，在发酵时同步产生透明质酸与乳酸两种产物，此时加入纳米纤维素可使其在生物作用下形成凝胶，对其进行红外，SEM，XRD,流变等方面的测试，探究纳米纤维素与兽疫链球菌发酵的最佳条件。

关键词：纳米纤维素；透明质酸；水凝胶；应用

In situ Gelation of Nanocellulose by Streptococcus zooepidemicus in Mid-fermentation Period

ABSTRACT

Nanocellulose, as a new biomass nanomaterial, has been proved to be a promising self-assembled hydrogels or bio-based nanocellulose fillers. Hyaluronic acid is widely used in medicine and cosmetics industry because of its strong water retention ability. Hydrogels are a kind of polymer materials with three-dimensional network structure made of synthetic polymers and natural polymers. Due to their high water content and high elastic behavior, hydrogels have been widely used in tissue filling materials, drug carriers, cartilage regeneration, wound dressings and environmental adsorbents. Hyaluronic acid and nanocellulose can be combined to produce green, safe, healthy and non-toxic new hydrogel composites. With Streptococcus zooepidemicus as inducer, two products of hyaluronic acid and lactic acid were produced simultaneously during fermentation. At this time, nano-cellulose could be added to form gel under biological action. Infrared, SEM, XRD, rheology and other aspects of the gel were tested to explore the best conditions for the fermentation of nano-cellulose and Streptococcus zooepidemicus.

Keywords：Nanocellulose；HA；Water gel；application

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