Evaluation of 8-MOP and lipopolysaccharide co-treatment-induced liver injury.
8-MOP与脂多糖联合治疗肝损伤的评价
8-Methoxypsoralen (8-MOP) is one of furanocoumarins clinically used for the treatment of vitiligo and psoriasis1,2. Despite its widely used, potential 8-MOP-induced liver injury has been observed in both human and animals, with high serum gamma;-glutamyl transpeptidase (gamma;-GGT), total bilirubin (TBIL), and alanine aminotransferase (ALT) levels3-6.
Even though studies had been carried out to explore the 8-MOP toxicity, there still lack of evidence to explain the hepatotoxic mechanism. Reports have shown that inflammatory stress may increase sensitivity towards drug-induced liver injury (DILI)7,8. Lipopolysaccharide (LPS) is a Gram-negative bacterial outer cell wallrsquo;s membrane constituent, which comprehensively studied as an inflammatory agent which might intensify DILI9-12. It has been reported that exposure to smaller, injury-free LPS concentrations that unable to cause tissue or cellular damage, will elevate drugs intoxication liabilities13,14. Therefore, animal models that follow the inflammatory stress theory, in which non-toxic LPS doses potentiate drug toxicities, were of great help in mechanistically elaborating DILI general picture. So, this study aimed to prove the hypothesis that co-exposure to both 8-MOP and LPS might intensify 8-MOP-induced liver injur
REFERENCES
1. Bethea D, Fullmer B, Syed S, et al. Psoralen photobiology and photochemotherapy: 50 years of science and medicine. Journal of Dermatological Science. 1999;19(2):78-88.
2. Parrish JA, Fitzpatrick TB, Shea C, Pathak MA. Photochemotherapy of vitiligo. Use of orally administered psoralens and a high-intensity long-wave ultraviolet light system. Archives of dermatology. 1976;112(11):1531-1534.
3. Bjellerup M, Bruze M, Hansson A, Krook G, Ljunggren B. Liver injury following administration of 8-methoxypsoralen during PUVA therapy. Acta dermato-venereologica. 1979;59(4):371-372.
4. Pariser DM, Wyles RJ. Toxic hepatitis from oral methoxsalen photochemotherapy (PUVA). Journal of the American Academy of Dermatology. 1980;3(3):248-250.
5. Cheung WI, Tse ML, Ngan T, et al. Liver injury associated with the use of Fructus Psoraleae (Bol-gol-zhee or Bu-gu-zhi) and its related proprietary medicine. Clin Toxicol (Phila). 2009;47(7):683-685.
6. Zhao G, Xu D, Yuan Z, et al. 8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity. Toxicology. 2017;386:40-48.
以上是毕业论文文献综述，课题毕业论文、任务书、外文翻译、程序设计、图纸设计等资料可联系客服协助查找。
